PT  - JOURNAL ARTICLE
AU  - DAVID I. MACHT
TI  - CONCERNING THE POINT OF ATTACK OF PITUITARY EXTRACT AND HISTAMINE ON SMOOTH MUSCLE
DP  - 1926 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 389--393
VI  - 27
IP  - 5
4099  - http://jpet.aspetjournals.org/content/27/5/389.short
4100  - http://jpet.aspetjournals.org/content/27/5/389.full
SO  - J Pharmacol Exp Ther1926 Jun 01; 27
AB  - The above experiments indicate clearly two conclusions. In the first place both pituitary extracts and histamine act directly upon muscle substance without the intermediary of a nervous mechanism. In the second place, the highly potent body A derived by Professor Abel from the pituitary gland also acts directly upon muscle substance but is much more powerful, as little as 1:5,000,000 of it giving a maximal response. This would tend to give additional evidence to that already adduced by Abel and his collaborators in regard to the nature of the pituitary principle.