@article {GRUBER349, author = {CHARLES M. GRUBER and SAMUEL J. ROBERTS}, title = {V. THE EFFECT OF PHENOBARBITAL "LUMINAL" AND SOME OTHER BARBITURIC ACID DERIVATIVES UPON CEREBRAL CIRCULATION}, volume = {27}, number = {4}, pages = {349--354}, year = {1926}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {1. All the barbituric acid derivatives tested cause dilatation of the cerebral vessels. 2. Sodium phenobarbital 50 or 100 mgm. When dissolved in Ringer{\textquoteright}s solution pH 7.6 modified by the addition of autogenous defibrinated blood to 20 per cent and injected into a perfusate of the same fluid produced marked cerebral vaso-dilatation. If the same quantity of sodium phenobarbital is dissolved in Ringer{\textquoteright}s solution pH 7.6 and injected into a perfusion fluid of Ringer{\textquoteright}s pH 7.6 having the same temperature etc., vaso-constriction resulted. 3. The vaso-constriction noted with sodium phenobarbital is due, we believe, to the change in pH of the fluid perfusing through the brain. 4. Fluids with a pH less than the perfusate when injected into it increase the rate of perfusion flow (vaso-dilatation) and fluids with a pH greater than that of the perfusate when similarly injected cause decreased rate of perfusion flow (vaso-constriction). 5. In the brain as in other organs the barbituric acid derivatives act directly upon the vessel wall in producing vaso-dilatation. 6. The beneficial results from the administration of phenobarbital in epilepsy may be in part, due to its cerebral vaso-dilator action.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/27/4/349}, eprint = {https://jpet.aspetjournals.org/content/27/4/349.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }