PT  - JOURNAL ARTICLE
AU  - P Y Wong
AU  - G Yue
AU  - K Yin
AU  - M Miyasaka
AU  - C L Lane
AU  - A M Manning
AU  - D C Anderson
AU  - F F Sun
TI  - Antibodies to intercellular adhesion molecule-1 ameliorate the inflammatory response in acetic acid-induced inflammatory bowel disease.
DP  - 1995 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 475--480
VI  - 274
IP  - 1
4099  - http://jpet.aspetjournals.org/content/274/1/475.short
4100  - http://jpet.aspetjournals.org/content/274/1/475.full
SO  - J Pharmacol Exp Ther1995 Jul 01; 274
AB  - The transendothelial migration of leukocytes in many inflammatory responses is now believed to be dependent on the interaction of leukocyte and endothelial cell-derived adhesion molecules. To examine the role of intercellular adhesion molecule-1 (ICAM-1) in the development of inflammation in a rat model of colitis, we investigated the effects of antibodies to rat ICAM-1 given 24 hrs after inflammation was induced by acetic acid. Antibodies to rat ICAM-1 substantially ameliorated the inflammatory response as indicated by a reduction in gross inflammatory characteristics, tissue/body weight ratio, myeloperoxidase activity and superoxide levels. The results demonstrate that ICAM-1 plays an important role in the development of inflammatory bowel disease in rats. The use of antibodies to ICAM-1 to inhibit the adherence of leukocytes to endothelium, may be of potential therapeutic value in the treatment of inflammatory bowel disease in man.