PT  - JOURNAL ARTICLE
AU  - D J Carr
AU  - C P France
TI  - Immune alterations in morphine-treated rhesus monkeys.
DP  - 1993 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 9--15
VI  - 267
IP  - 1
4099  - http://jpet.aspetjournals.org/content/267/1/9.short
4100  - http://jpet.aspetjournals.org/content/267/1/9.full
SO  - J Pharmacol Exp Ther1993 Oct 01; 267
AB  - The effect of morphine treatment on immunocompetence was investigated in rhesus monkeys (Mucaca mulatta). Monkeys that received morphine daily (3.2 mg/kg) had suppressed peripheral blood mononuclear cell (PBMC) natural killer (NK) activity as well as a decrease in the percentage of CD8+CD16+ cells compared with saline-treated (controls) or infrequently treated (i.e., opioids once or twice weekly) monkeys. However, an increase (20 +/- 5%) in the percentage of CD8+ lymphocytes was found in both the daily and infrequent opioid-treated monkeys compared with controls. Conversely, the percentage of total CD4+ lymphocytes and CD4+CD45RA+ was reduced (12 +/- 2% and 28 +/- 10% respectively) in both daily and infrequent opioid-treated animals compared with saline-treated controls. In a reciprocal fashion, there was an increase in the CD4+CD29+ population in daily morphine-treated monkeys (54% of the total CD4+ cells) compared with untreated animals (37% of the total CD4+ cells). In addition, cultured PBMC obtained from monkeys treated daily with morphine produced significantly (P < .01) more polyclonal immunoglobulin (Ig) G (366 ng/ml) and polyclonal IgM (233 ng/ml) compared with PBMC production of polyclonal IgG (96 ng/ml) and polyclonal IgM (67 ng/ml) from saline-treated controls. However, no differences were found in the percentage of CD19+ lymphocytes among any of the groups. In summary, daily treatment with a relatively low dose of morphine (3.2 mg/kg) affects immunocompetence which could have important implications in the regulation of viral pathogens in i.v. drug abusers (e.g., AIDS).