RT Journal Article
SR Electronic
T1 A CONTRIBUTION TO THE STUDY OF THE METABOLISM OF SALICYLIC ACID
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 297
OP 314
VO 26
IS 4
A1 HOLMES, E. G.
YR 1925
UL http://jpet.aspetjournals.org/content/26/4/297.abstract
AB 1. After the ingestion of salicylates by a normal individual on a mixed diet, salicyluric acid was isolated from the urine, and identified. The identification rested on solubility, amino and total nitrogen content, which were satisfactory, and melting point, which was identical with a pure specimen of synthetic salicyluric acid. 2. For doses of sodium salicylate of from 2 to 5 grams, the salicylic/salicyluric ratio is constant at the value of .40/60. 3. This ratio, after the ingestion of 1.5 grams of synthetic salicyluric acid, reaches the value of 8/92. 4. The distillation method for the estimation of total salicyl in urine, described by Hanzlik, is not satisfactory when solutions of pure salicyluric acid in urine are employed. 5. No evidence has been found for the destruction of salicylic acid in the body. 6. Under the conditions of these experiments, no salicyl-glycuronic compound was excreted.