PT  - JOURNAL ARTICLE
AU  - Safayhi, H
AU  - Mack, T
AU  - Sabieraj, J
AU  - Anazodo, M I
AU  - Subramanian, L R
AU  - Ammon, H P
TI  - Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.
DP  - 1992 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 1143--1146
VI  - 261
IP  - 3
4099  - http://jpet.aspetjournals.org/content/261/3/1143.short
4100  - http://jpet.aspetjournals.org/content/261/3/1143.full
SO  - J Pharmacol Exp Ther1992 Jun 01; 261
AB  - Isomers (alpha- and beta-) of boswellic acids (BAs), 11-keto-beta-BA and their acetyl derivatives were isolated from the gum resin of Boswellia serrata. BA and derivatives concentration dependently decreased the formation of leukotriene B4 from endogenous arachidonic acid in rat peritoneal neutrophils. Among the BAs, acetyl-11-keto-beta-BA induced the most pronounced inhibition of 5-lipoxygenase (5-LO) product formation with an IC50 of 1.5 microM. In contrast to the redox type 5-LO inhibitor nordihydroguaiaretic acid, BA in concentrations up to 400 microM did not impair the cyclooxygenase and 12-lipoxygenase in isolated human platelets and the peroxidation of arachidonic acid by Fe-ascorbate. The data strongly suggest that BAs are specific, nonreducing-type inhibitors of the 5-LO product formation either interacting directly with the 5-LO or blocking its translocation.