PT - JOURNAL ARTICLE AU - J T Eells AU - M L Dubocovich TI - Pyrethroid insecticides evoke neurotransmitter release from rabbit striatal slices. DP - 1988 Aug 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 514--521 VI - 246 IP - 2 4099 - http://jpet.aspetjournals.org/content/246/2/514.short 4100 - http://jpet.aspetjournals.org/content/246/2/514.full SO - J Pharmacol Exp Ther1988 Aug 01; 246 AB - The effects of the synthetic pyrethroid insecticide fenvalerate ([R,S]-alpha-cyano-3-phenoxybenzyl[R,S]-2-(4-chlorophenyl)-3- methylbutyrate) on neurotransmitter release in rabbit brain slices were investigated. Fenvalerate evoked a calcium-dependent release of [3H]dopamine and [3H]acetylcholine from rabbit striatal slices that was concentration-dependent and specific for the toxic stereoisomer of the insecticide. The release of [3H]dopamine and [3H]acetylcholine by fenvalerate was modulated by D2 dopamine receptor activation and antagonized completely by the sodium channel blocker, tetrodotoxin. These findings are consistent with an action of fenvalerate on the voltage-dependent sodium channels of the presynaptic membrane resulting in membrane depolarization, and the release of dopamine and acetylcholine by a calcium-dependent exocytotic process. In contrast to results obtained in striatal slices, fenvalerate did not elicit the release of [3H]norepinephrine or [3H]acetylcholine from rabbit hippocampal slices indicative of regional differences in sensitivity to type II pyrethroid actions.