PT  - JOURNAL ARTICLE
AU  - G Maura
AU  - A Giardi
AU  - M Raiteri
TI  - Release-regulating D-2 dopamine receptors are located on striatal glutamatergic nerve terminals.
DP  - 1988 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 680--684
VI  - 247
IP  - 2
4099  - http://jpet.aspetjournals.org/content/247/2/680.short
4100  - http://jpet.aspetjournals.org/content/247/2/680.full
SO  - J Pharmacol Exp Ther1988 Nov 01; 247
AB  - The effects of dopamine (DA) and other dopaminergic receptor agonists on the depolarization-evoked release of endogenous glutamic acid (GLU) have been studied using synaptosomes prepared from rat corpus striatum and depolarized in superfusion with 15 mM KCl. DA and the selective D-2 receptor agonists quinpirole (LY-171555, the levorotatory enantiomer of LY-141865) and pergolide inhibited GLU release in a concentration-dependent way. The natural agonist was particularly effective causing 50% inhibition of GLU release at 10 nM. In contrast, the selective D-1 receptor agonist SK&F 38393 did not affect the release of GLU. The inhibitory effect of DA on the K+-evoked release of GLU was antagonized in a concentration-dependent manner by the selective D-2 receptor antagonist S-sulpiride, but not by the R-enantiomer. The data represent a direct demonstration that receptors sensitive to nanomolar concentrations of DA and belonging to the D-2 type are located on GLU axon terminals in the rat corpus striatum where they may modulate the release of GLU from glutamatergic afferents including the cortico-striatal pathway.