RT Journal Article
SR Electronic
T1 Endothelial injury provokes collateral arterial vasoconstriction: response to a serotonin 2 antagonist, thromboxane antagonist or synthetase inhibition.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 1164
OP 1168
VO 244
IS 3
A1 N K Hollenberg
A1 K Monteiro
A1 T Sandor
YR 1988
UL http://jpet.aspetjournals.org/content/244/3/1164.abstract
AB To assess the influence on collateral arteries of vasoactive factors released from activated platelets we used angiography and blood flow measurement to study the limb blood supply in 29 rabbits, 2 weeks after superficial femoral artery ligation. Minutes after balloon catheter injury to the lower aorta, striking spasm of the collateral arteries was routinely evident on the arteriograms, and limb blood flow fell. Spasm was partly reversed either by blockade of thromboxane synthesis (UK-38,485) or its vascular action (SQ 29,548) or by ketanserin, the serotonin receptor antagonist when used alone. Ketanserin combined with either UK-38,485 or SQ 29,548 reversed the spasm completely. We conclude that a combined action of serotonin and thromboxane induces collateral artery spasm when platelets are activated.