PT  - JOURNAL ARTICLE
AU  - G R Peters
AU  - N J Ward
AU  - E G Antal
AU  - P Y Lai
AU  - E W deMaar
TI  - Diuretic actions in man of a selective kappa opioid agonist: U-62,066E.
DP  - 1987 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 128--131
VI  - 240
IP  - 1
4099  - http://jpet.aspetjournals.org/content/240/1/128.short
4100  - http://jpet.aspetjournals.org/content/240/1/128.full
SO  - J Pharmacol Exp Ther1987 Jan 01; 240
AB  - The effect of a selective kappa opioid agonist, U-62,066E, on urine formation in human volunteers was assessed. Volunteers received single intramuscular injections of either placebo or 2, 3, 4, 5 or 6 micrograms/kg of U-62,066E in a randomized, double-blind study. U-62,066E caused dose-dependent maximal increases in urine volume of 2.6 times control in the first 4 hr after administration. A corresponding decrease in urine osmolality to 20% of base-line values occurred. No changes in total urinary Na, K or Cl excretion were identified. Kappa agonists produce a water-only diuresis at low doses in humans. The mechanism of this effect was not examined in this study but probably relates to alterations in antidiuretic hormone activity.