PT  - JOURNAL ARTICLE
AU  - Hall, S
AU  - Rowland, M
TI  - Influence of fraction unbound upon the renal clearance of furosemide in the isolated perfused rat kidney.
DP  - 1985 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 263--268
VI  - 232
IP  - 1
4099  - http://jpet.aspetjournals.org/content/232/1/263.short
4100  - http://jpet.aspetjournals.org/content/232/1/263.full
SO  - J Pharmacol Exp Ther1985 Jan 01; 232
AB  - The influence of fraction furosemide unbound (varied over a 28-fold range) upon its renal clearance was studied in an isolated perfused rat kidney, while renal function was maintained. Renal clearance and unbound fraction of furosemide were found to be related linearly, the average unbound renal clearance being 3.3 ml min-1. Urine pH and urine flow rate did not influence furosemide renal clearance in the ranges experienced in this study. Our results are consistent with those predicted from a consideration of the kinetics of renal excretion.