PT  - JOURNAL ARTICLE
AU  - H Satoh
AU  - J Inui
AU  - T Kimura
AU  - T Nakamura
TI  - Development of histamine tachyphylaxis in the guinea-pig mesenteric artery.
DP  - 1984 May 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 527--531
VI  - 229
IP  - 2
4099  - http://jpet.aspetjournals.org/content/229/2/527.short
4100  - http://jpet.aspetjournals.org/content/229/2/527.full
SO  - J Pharmacol Exp Ther1984 May 01; 229
AB  - Histamine, norepinephrine and KCl each evoke contractile responses in isolated guinea-pig mesenteric artery. However, only the contractile response to histamine was characterized by acute desensitization or tachyphylaxis. The tachyphylaxis observed to histamine was independent of the time interval between successive administrations up to at least 1 hr. The histamine H1-receptor blocker, chlorpheniramine (10(-9) M), completely inhibited contractile responses to histamine (10(-5) M). In contrast, metiamide (10(-4) M), an H2-receptor blocker, potentiated contractions which were characterized by tachyphylaxis. Propranolol (10(-6) M), phentolamine (10(-6) M) and atropine (10(-6) M) affected neither the contractile response itself nor the tachyphylaxis to histamine (10(-5) M). Indomethacin (10(-5) M) and aspirin (3 X 10(-4) M) potentiated the initial contraction induced by histamine (10(-5) M) and completely abolished the tachyphylaxis. The response to the initial application of histamine (10(-5) M) was not affected by the reduction of [Ca++] to 0.25 mM or by diltiazem (10(-5) M) or verapamil (10(-5) M). The tachyphylaxis to histamine was, however, suppressed slightly but significantly by the reduction of [Ca++]o and by Ca++ antagonists. These results suggest that the development of tachyphylaxis to histamine in the isolated guinea-pig mesenteric artery may result from the production of prostaglandins which are sensitive to Ca++.