PT  - JOURNAL ARTICLE
AU  - A S Koster
AU  - J Noordhoek
TI  - Glucuronidation in isolated perfused rat intestinal segments after mucosal and serosal administration of 1-naphthol.
DP  - 1983 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 533--538
VI  - 226
IP  - 2
4099  - http://jpet.aspetjournals.org/content/226/2/533.short
4100  - http://jpet.aspetjournals.org/content/226/2/533.full
SO  - J Pharmacol Exp Ther1983 Aug 01; 226
AB  - Glucuronidation of 1-naphthol in the rat intestinal wall was studied in isolated perfused intestinal segments. 1-Naphthol glucuronide appeared on the mucosal as well as on the serosal side of the intestinal segments irrespective of the side (mucosal and/or serosal) on which naphthol was administered. Appearance of naphthol glucuronide was linear with time. A lag phase of 3.9 +/- 0.9 and 4.3 +/- 1.0 min was observed for the appearance on the mucosal and serosal side, respectively. Total glucuronide appearance rate after serosal administration of 10 to 100 microM naphthol was 3- to 4-fold higher than after mucosal administration. It is concluded that glucuronidation after mucosal administration is limited by the entry of naphthol into the metabolizing compartment.