@article {Clohisy49, author = {D R Clohisy and A P Quintanilla and T P Gibson}, title = {Effect of quinidine on the renal clearance of digoxin in the presence of low and high serum digoxin concentrations.}, volume = {222}, number = {1}, pages = {49--51}, year = {1982}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The effect of an infusion of quinidine, 180 micrograms/kg/Min (base) on the fractional clearance of digoxin (CDIG/Cin) was studied in saline volume-expanded dogs given a constant infusion of digoxin of either 0.0067 micrograms/kg/min (low dose) or 0.120 micrograms/kg/min (high dose). CDIG/CIN decreased 28\% from 1.42 +/- 0.36 during control periods to 1.01 +/- 0.03 (P less than .05) with quinidine in dogs given the low dose. In dogs given the high dose of digoxin, CDIG/CIN decreased 22\% from 0.76 +/- 0.17 to 0.59 +/- 0.05 (p less than .05) with quinidine. It is concluded that quinidine reduces CDIG/CIN. High doses of digoxin also reduce CDIG/CIN. Inasmuch as quinidine reduces CDIG/CIN to the same extent in the presence of low or high dose digoxin, the effect of quinidine would appear to be mediated through a mechanism different from that of digoxin.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/222/1/49}, eprint = {https://jpet.aspetjournals.org/content/222/1/49.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }