PT  - JOURNAL ARTICLE
AU  - Y H Chang
AU  - R Bluestone
TI  - Adjuvant polyarthritis. VI. Effect of oxonate-induced hyperuricemia on the development of acute inflammation, immune response and adjuvant arthritis.
DP  - 1981 Dec 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 731--734
VI  - 219
IP  - 3
4099  - http://jpet.aspetjournals.org/content/219/3/731.short
4100  - http://jpet.aspetjournals.org/content/219/3/731.full
SO  - J Pharmacol Exp Ther1981 Dec 01; 219
AB  - In humans, there is a negative correlation between gout and rheumatoid arthritis. Similarly, rats rendered hyperuricemic by an oxonate diet appeared resistant to develop adjuvant arthritis. These animals exhibited a normal inflammatory response to a subplantar injection of carrageenin and normal humoral and cell-mediated immune responses to a sensitizing dose of EL4 cells. However, unlike that of normal animals, the cell-mediated immune system of the oxonate-treated rats was found to be unable to respond to adjuvant stimulation, which may be the basis for their resistance to develop adjuvant disease.