TY - JOUR T1 - The effect of ethanol on the fate of mercury vapor inhaled by man. JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 520 LP - 527 VL - 214 IS - 3 AU - J B Hursh AU - M R Greenwood AU - T W Clarkson AU - J Allen AU - S Demuth Y1 - 1980/09/01 UR - http://jpet.aspetjournals.org/content/214/3/520.abstract N2 - Three human subjects ingested 1065 ml of beer equivalent to 65 ml of ethanol 30 min before exposure (12-20 min) to mercury vapor. An additional two subjects were exposed to mercury vapor without ethanol pretreatment. The results show that alcohol brings about: 1) reduced mercury retention, 2) an increase in the rapid phase of vapor loss by expiration, 3) an increased mercury storage in the liver, 4) a marked reduction in mercury uptake by the red blood cells and 5) the abolition of vapor exposure experiments were performed by using control and ethanol-pretreated mice and rats. Sacrifice occurred at 1 hr and 3 days. The results support and extend the human data. ER -