RT Journal Article SR Electronic T1 Clonidine-induced hyperglycemia: evidence against a growth hormone-mediated effect. JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 433 OP 436 VO 214 IS 2 A1 C Barbieri A1 C Ferrari A1 R Caldara A1 G Testori A1 G A Dal Bo A1 A Bertazzoni YR 1980 UL http://jpet.aspetjournals.org/content/214/2/433.abstract AB The effects of acute clonidine infusion (0.15 mg over 10 min) on several endocrine and metabolic variables have been evaluated in 12 hypertensive patients and 12 normotensive controls. Plasma glucose increased significantly in comparison with a placebo study in both groups; serum growth hormone showed a significant increase in healthy subjects but did not rise in hypertensive patients; there was no correlation between the increments in plasma glucose and in serum growth hormone in the whole group of subjects; serum-free fatty acids, insulin, prolactin and plasma cortisol did not change in any group. These data, although not excluding a central site of the clonidine hyperglycemic action, contrast the view that it may depend on stimulation of growth hormone release.