RT Journal Article
SR Electronic
T1 DOES THE REACTION TO ADRENALIN OBEY WEBER'S LAW?
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 229
OP 235
VO 21
IS 4
A1 D. MURRAY LYON
YR 1923
UL http://jpet.aspetjournals.org/content/21/4/229.abstract
AB 1. Repeated doses of a uniform amount of adrenalin chloride solution produce the same increase in blood pressure only if the resting level of the pressure immediately preceding the injection is the same in each case. 2. When the resting levels differ, the blood pressure responses to uniform doses of adrenalin vary, the magnitude of the disturbance diminishing as the resting level rises. In other words, a much larger dose is required to produce the same effect at a higher level. 3. When the amount of adrenalin administered is increased arithmetically, the resultant blood pressure rises do not follow suit but bear a logarithmic relationship to the stimulus, obeying the Weber-Fechner Law.