RT Journal Article
SR Electronic
T1 Liberation of cyanide from alpha-aminonitriles relative to amygdalin.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 751
OP 756
VO 205
IS 3
A1 M B Winstead
A1 C A Ciccarelli
A1 H S Winchell
YR 1978
UL http://jpet.aspetjournals.org/content/205/3/751.abstract
AB A series of aminoitriles have been synthesized and studied whose nonenzymatic dissociation with release of cyanide may be varied by modest alteration of their molecular structure from that obtained with nonenzymatic dissociation of amygdalin to that obtained from enzymatic dissociation of amygdalin by substantial quantities of beta-glucosidase. The relationship between such alterations in molecular structure and nonenzymatic dissociation is discussed. A combination of the results of these studies and studies relating molecular structure to physical localization propensity in tumors has potential in the design of chemotherapeutic agents.