@article {Dekin319, author = {M S Dekin and H R Guy and C Edwards}, title = {Effects of organophosphate insecticides on the cholinergic receptors of frog skeletal muscle.}, volume = {205}, number = {2}, pages = {319--325}, year = {1978}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {The organophosphates octamethyl pyrophosphoramide, Bidrin, and phosphoric acid 2,2-dichlorovinyl dimethyl ester inhibit the membrane voltage response of frog sartorius muscles to carbamylcholine in a manner expected of either a slowly reversing competitive inhibitor or a noncompetitive inhibitor. The inhibition reverses with a time course of minutes, depending upon the temperature. The inhibition by these compounds is reduced by d-tubocurarine but is unaffected by hexamethonium. This may indicate that the organophosphate binding sites are near the cholinergic binding site since both d-tubocurarine and hexamethonium are competitive inhibitors of cholinergic agonists and d-tubocurarine is the larger compound.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/205/2/319}, eprint = {https://jpet.aspetjournals.org/content/205/2/319.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }