PT  - JOURNAL ARTICLE
AU  - Zakrzewski, S F
AU  - Dave, C
AU  - Mead, L H
AU  - Deluomo, D S
TI  - Studies with a new antifolate 2,4-diamino-5-adamantyl-6-methylpyrimidine (DAMP): tissue distribution and disposition of 2,4-diamino-5-adamantyl-6-methylpyrimidine and its metabolite.
DP  - 1978 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 19--26
VI  - 205
IP  - 1
4099  - http://jpet.aspetjournals.org/content/205/1/19.short
4100  - http://jpet.aspetjournals.org/content/205/1/19.full
SO  - J Pharmacol Exp Ther1978 Apr 01; 205
AB  - The pharmacokinetics of a potentially useful antitumor agent, 2,4-diamino-5-adamantyl-6-methylpyrimidine (DAMP) has been studied in rat using 14C-labeled drug. It is reported that DAMP is metabolized rapidly by liver microsomes to an unidentified compound. The metabolite seems to be excreted by liver more rapidly than the unchanged drug, and within 24 hours all radioactivity is eliminated, 80% through kidney and 20% through the bile. Both DAMP, and its metabolite accumulate readily in pancreas and kidney. In contrast, in the brain mostly unchanged DAMP could be detected. The accumulation of the drug in tissues other than liver is much greater after i.v. than after i.p. administration.