TY - JOUR T1 - INFLUENCE OF ARSPHENAMINE AND NEOARSPHENAMINE ON THE EPINEPHRINE CONTENT OF THE ADRENAL GLANDS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 153 LP - 162 VL - 20 IS - 2 AU - BALDWIN LUCKE AU - JOHN A. KOLMER AU - GRAYSON P. McCOUCH Y1 - 1922/09/01 UR - http://jpet.aspetjournals.org/content/20/2/153.abstract N2 - The right adrenal glands of rabbits injected with single doses of arsphenamine and neoarsphenamine, in from two to five times the corresponding therapeutic amounts, were assayed for their quantitative epinephrine contents by the biological method of Elliott. A considerable range of values was obtained, but on the average, the amounts were almost identical with the average of the epinephrine values of control rabbits. The right adrenal glands of rabbits injected with two to twelve "therapeutic" doses of arsphenamine and neoarsphenamine gave, on the average, epinephrine values slightly less than those of control rabbits. Of nine animals receiving multiple injections only one (no. 23) shows a reduction beyond the range of the controls. No striking difference was found between the influence of arsphenamine or neoarsphenamine, nor did the time of survival after injection appear to play any appreciable rĂ´le. Histological studies of the corresponding left glands did not show any noticeable and constant alterations of the chromaffine reaction. The lipoids appeared very slightly increased after a single injection, and slightly decreased after multiple injections. ER -