RT Journal Article
SR Electronic
T1 Reinstatement of vaginal cycles in aged female rats.
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 477
OP 482
VO 199
IS 2
A1 M Linnoila
A1 R L Cooper
YR 1976
UL http://jpet.aspetjournals.org/content/199/2/477.abstract
AB Old constant estrous and young cycling control rats were injected with L-dopa, 200 mg/kg, for a period of 14 days. L-Dopa reinstated vaginal cycling in the old rats and it did not affect the vaginal cycling in young rats. Likewise, 200 mg/kg of L-tyrosine reinstated vaginal cycling. The effect of L-dopa on old rats was blocked by pimozide, by high doses of MK-486 and Ro 4-4602, and by fusaric acid. High doses of phenoxybenzamine or L-propranolol did not alter the L-dopa effect on old rats. A low dose of MK-486 or Ro 4-4602 increased the efficacy of L-dopa in reinstating vaginal cycling. These results suggest that L-dopa reinstates vaginal cycling in old rats by stimulating dopamine receptors. The possibility that a simultaneous stimulation of norepinephrine alpha and beta receptors and/or a decrease of central nervous system serotonin is necessary for this effect is discussed.