PT  - JOURNAL ARTICLE
AU  - L Diamond
AU  - G K Adams
AU  - B Bleidt
AU  - B Williams
TI  - Experimental study of a potential anti-asthmatic agent: SCH 15280.
DP  - 1975 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 256--263
VI  - 193
IP  - 1
4099  - http://jpet.aspetjournals.org/content/193/1/256.short
4100  - http://jpet.aspetjournals.org/content/193/1/256.full
SO  - J Pharmacol Exp Ther1975 Apr 01; 193
AB  - A forced oscillations technique for measuring total respiratory system resistance was used to quantitate the bronchomotor activity of Sch 15280: (5[4-(N-methyl)-piperidylidine]5H-[1]-benzopyrano[2,3,b]-pyridine maleate) and to compare its potency to that of standard bronchodilator agents. By the intravenous route, Sch 15280 was 48 times more potent than aminophylline and 1/78 as potent as atropine in inhibiting methacholine-induced bronchoconstriction in rabbits. In cats Sch 15280 was 1/12 as potent as ephedrine in inhibiting histamine-induced bronchoconstriction and had a greater protective activity against histamine-induced bronchoconstriction and had a longer duration of action than 0.5% solution of isoproterenol. Statistical tests of parallelism revealed a significant difference between the log dose-response curves of Sch 15280 and ephedrine but not between those of Sch 15280, atropine and aminophylline. The results suggest that Sch 15280 can act via, a nonadrenergic mechanism to block both histaminergically and cholinergically mediated responses in the tracheobronchial tree. This pharmacologie profile may have important therapeutic application in the type I immediate hypersensitivity reactions of man.