PT  - JOURNAL ARTICLE
AU  - R D Miller
AU  - L S Van Nyhis
AU  - E I Eger
TI  - The effect of temperature on a d-tubocurarine neuromuscular blockade and its antagonism by neostigmine.
DP  - 1975 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 237--241
VI  - 195
IP  - 2
4099  - http://jpet.aspetjournals.org/content/195/2/237.short
4100  - http://jpet.aspetjournals.org/content/195/2/237.full
SO  - J Pharmacol Exp Ther1975 Nov 01; 195
AB  - In 19 cats anesthetized with chloralose and urethrane, d-tubocurarine (d-TC) was continuously infused to produce constant 90% depression of twitch tension prior to injection of 5, 10 or 20 mug/kg of neostigmine. The required mean infusion rates of d-TC were 3.6 +/- 0.6, 5.1 +/- 0.3, 8.5 +/- 0.3 and 8.9 +/- 0.5 mug/kg/min at body and muscle temperatures of 28, 31, 37 and 41 degrees C, respectively. The doses of neostigmine needed for 50% antagonism of the d-TC-induced depression of twitch height were 8.7, 9.2, 10.5 and 12.0 mug/kg at 28, 31, 37 and 41 degrees, respectively. The time to peak effect and duration of action of 5 and 10 mug/kg of neostigmine were longer at 28 and 31 degrees C than at 37 and 41 degrees C. Although these times also were longer at 27 and 31 degrees C with the 20 mug/kg dose of neostigmine, they were not statistically different. We conclude that hypothermia augments a d-TC neuromuscular blockade. Hypothermia prolongs time-to-peak effect and duration of neostigmine but does not affect peak magnitude of antagonism of d-TC by neostigmine.