PT  - JOURNAL ARTICLE
AU  - K H Beyer, Jr
AU  - R T Gelarden
TI  - Functional characteristics of the renal tubular secretion of amprolium, a quaternary organic base.
DP  - 1975 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 194--200
VI  - 195
IP  - 2
4099  - http://jpet.aspetjournals.org/content/195/2/194.short
4100  - http://jpet.aspetjournals.org/content/195/2/194.full
SO  - J Pharmacol Exp Ther1975 Nov 01; 195
AB  - Amprolium [1-(4-amino-2-propyl-5-pyrimidinemethyl)-2-methyl-pyridinium chloride hydrochloridel is a basic (quaternary) organic compound. At very low plasma concentration, it is cleared by the kidney at a rate approximating renal plasma flow in the dog. Its renal clearance is not depressed by organic acids (p-aminohippurate or probenecid) but is reduced by the quaternary base, mepiperphenidol. Acetate and pantothenate may influence the clearance of amprolium but, if this is the case, the effect is less than for p-aminohippurate. Its clearance is depressed as urinary pH is increased. The clearance of amprolium was not altered over a substantial range in urine flow at either high or low urinary pH.