PT  - JOURNAL ARTICLE
AU  - Branisteanu, D D
AU  - Volle, R L
TI  - Modification by lithium of transmitter release at the neuromuscular junction of the frog.
DP  - 1975 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 362--372
VI  - 194
IP  - 2
4099  - http://jpet.aspetjournals.org/content/194/2/362.short
4100  - http://jpet.aspetjournals.org/content/194/2/362.full
SO  - J Pharmacol Exp Ther1975 Aug 01; 194
AB  - Complete or partial replacement of Na+ by Li+ resulted in a progressively developing increase in the amplitude and quantal content of end-plate potentials of the frog neuromuscular junction. Analysis of frequency facilitation curves and estimations of the binomial parameters of release indicate that Li+ caused an increase in the probability of transmitter release. Li+ also caused a time dependent increase in the frequency of miniature end-plate potentials. The responsiveness of the miniature end-plate potentials to Li+ was depressed by elevated Ca++ and enhanced by elevated K+. Collectively, the effects of Li+ on transmitter release can be attributed to the accumulation by the nerve terminals of Li+ resulting on an increased level of intracellular Ca++.