PT - JOURNAL ARTICLE AU - Stanley Greenberg AU - Linda Howard AU - James Engelbrecht AU - William R. Wilson TI - EFFECTS OF PROSTAGLANDINS B<sub>1</sub> AND B<sub>2</sub> ON VASOCONSTRICTOR RESPONSES OF THE CANINE HINDPAW DP - 1974 Jul 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 70--76 VI - 190 IP - 1 4099 - http://jpet.aspetjournals.org/content/190/1/70.short 4100 - http://jpet.aspetjournals.org/content/190/1/70.full SO - J Pharmacol Exp Ther1974 Jul 01; 190 AB - The effects of prostaglandin B1 (PGB1) and prostagiandin B2 (PGB2) on the responses of the canine perfused hindpaw to adrenergic nerve stimulation and the pressor responses to intra-arterial injections of tymamine and norepineprhine were studied in 32 dogs. intra-arterial infusions of PGB2(50-200 ng/kg/min) produced concentration-dependent increases in the pressor responses to adrenergic nerve stimulation. The shift of the adrenergic nerve stimulation curve to the left during PGB2 infusion did not deviate from parallelism at either the low or high concentrations of PGB2. The pressor responses of the denervated paw to tyramine and norepinephrine were not altered during infusions of PGB2. Intra-arterial infusions of PGB1 produced effects similar to that of PGB2 but were less potent. Since PGB2 and PGB1 enhance the pressor responses to nerve stimulation, but not those to tyramine or norepinephrine, the data are consistent with the conclusion that PGB compounds facilitate release of the neurotransmitter from the norepinephrine pool uilized by the nerve action potential. In addition, the results suggest that the perfused canine hindpaw has a large propensity for vasoconstriction. © 1974 by The Williams &amp; Wilkins Company