PT  - JOURNAL ARTICLE
AU  - Clayton Petty
AU  - Thomas Bageant
TI  - THE EFFECT OF MORPHINE, MEPERIDINE, FENTANYL AND NALOXONE ON THE OXYHEMOGLOBIN DISSOCIATION CURVE
DP  - 1974 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 176--179
VI  - 190
IP  - 1
4099  - http://jpet.aspetjournals.org/content/190/1/176.short
4100  - http://jpet.aspetjournals.org/content/190/1/176.full
SO  - J Pharmacol Exp Ther1974 Jul 01; 190
AB  - Blood from 25 nonsmoking healthy volunteers was Screened for hematocrit, hemoglobin, hemoglobin electrophoresis and 2,3-diphosphoglycerate and then used in vitro to study the effects of morphine, meperidine, fentanyl and naloxone on hemoglobin affinity for oxygen. Morphine (1.4 µg/ml), meparidine (28.6 µg/ml) and naloxone (0.057 µg/ml) failed to alter the hemoglobin dissociation curve. Low doses of fentanyl (0.07 µg/ml and 0.36 µg/ml) shifted the curve to the left 1 to 1.5 mm Hg but a higher dose (0.71 µg/ml) failed to alter the curve. © 1974 by The Williams & Wilkins Company