PT  - JOURNAL ARTICLE
AU  - J H Mendelson
AU  - J E Mendelson
AU  - V D Patch
TI  - Plasma testosterone levels in heroin addiction and during methadone maintenance.
DP  - 1975 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 211--217
VI  - 192
IP  - 1
4099  - http://jpet.aspetjournals.org/content/192/1/211.short
4100  - http://jpet.aspetjournals.org/content/192/1/211.full
SO  - J Pharmacol Exp Ther1975 Jan 01; 192
AB  - Heroin use was consistently associated with low plasma testosterone levels in narcotic addicts. Heroin addicts maintained on high dosage methadone (80-150 mg/day) also had depressed testosterone levels. Patients on low dosage methadone maintenance (10-60 mg/day) had testosterone levels which were not significant;y different from normal adult male controls. An inverse relationship between methadone dosage and plasma testosterone occurred during methadone detoxification. These findings indicate that heroin and methadone alter male androgen levels with possible derivative effects upon sexual and aggressive behaviors.