PT  - JOURNAL ARTICLE
AU  - J Wax
AU  - C V Winder
AU  - D K Tessman
AU  - M D Stephens
TI  - Comparative activities, tolerances and safety of nonsteroidal anti-inflammatory agents in rats.
DP  - 1975 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 172--178
VI  - 192
IP  - 1
4099  - http://jpet.aspetjournals.org/content/192/1/172.short
4100  - http://jpet.aspetjournals.org/content/192/1/172.full
SO  - J Pharmacol Exp Ther1975 Jan 01; 192
AB  - Relative anti-inflammatory potencies of aspirin, phenylbutazone, indomethacin, three fenamates and several other nonsteroidal anti-inflammatory agents were obtained in several laboratory models of acute and chronic inflammation. Relative toxicities and ulcerogenicities were determined in rats of the same source, strain and sex. The acute ulcerogenic assay measures the minimal irritation potential of these agents and leads to a sensitive index of the safety of such compounds when compared with their therapeutic potencies. By these criteria, meclofenamic acid is a highly potent, acceptably safe and exceptionally well tolerated anti-inflammatory-antipyretic agent in rats when compared with other such drugs.