PT  - JOURNAL ARTICLE
AU  - R. Hākanson
AU  - L. -I. Larsson
AU  - F. Sundler
TI  - ENDOCRINE-LIKE CELLS IN RAT STOMACH: EFFECTS OF 6-HYDROXYDOPA ON AMINE STORES AND AMINO ACID DECARBOXYLASE ACTIVITIES. A CHEMICAL, FLUORESCENCE HISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDY
DP  - 1974 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 92--101
VI  - 191
IP  - 1
4099  - http://jpet.aspetjournals.org/content/191/1/92.short
4100  - http://jpet.aspetjournals.org/content/191/1/92.full
SO  - J Pharmacol Exp Ther1974 Oct 01; 191
AB  - The mucosa of the oxyntic gland area in the stomach of the rat contains two types of endocrine-like cells, belonging to a cell system referred to as enterochromaffin-like. It has previously been shown that both cell types produce and store histamine and that, if supplied with dopa, they are capable of producing and storing dopamine. Treatment with 6-hydroxydopa for 3 days caused marked activation of the histamine-forming enzyme, histidine decarboxylase, without affecting the histamine concentration. At the same time, 6-hydroxydopa treatment reduced the amount of dopamine appearing in the enterochromaffin-like cells after injection of L-dopa. Electron microscopic examination of the two types of endocrine-like cells revealed markedly swollen granules in one of the two cell types. No such effects were seen after treatment with 6-hydroxydopamine. It is suggested that the primary effect of 6-hydroxydopa is reflected in granular damage and that other cytochemical changes are secondary. © 1974 by The Williams & Wilkins Company