TY - JOUR T1 - N-GLUCOSIDE FORMATION AS A DETOXIFICATION MECHANISM IN MAMMALS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 563 LP - 569 VL - 190 IS - 3 AU - D. E. Duggan AU - J. J. Baldwin AU - B. H. Arison AU - R. E. Rhodes Y1 - 1974/09/01 UR - http://jpet.aspetjournals.org/content/190/3/563.abstract N2 - After intravenous dosage in dogs, the major portion of the xanthine oxidase inhibitor, 3-(4-pyrimidinyl)-5-(4-pynidyl)-1,2,4-triazole, is excreted in bile as a polar conjugate refractory to µ-glucuronidase, sulfatase, µ-glycosidase and nucleoside phosphorylase. High resolution mass spectrometry. nuclear magnetic resonance, absorption and fluorescence spectra, and identification of chemical hydrolysis produets of recrystallized conjugate have established its structure as the N-(1)-µ-D-glucopyranoside. The same conjugate is a sigificant component of renal and biliary elimination in the rat and monkey as well. These constitute the first reported instance of N-glucosylation as a detoxification mechanism in mammals. © 1974 by The Williams & Wilkins Co. ER -