RT Journal Article
SR Electronic
T1 PROSTAGLANDIN E<sub>1</sub>, ASPIRIN AND THE ACTION OF LEUKOCYTIC ENDOGENOUS MEDIATOR
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 516
OP 519
VO 188
IS 3
A1 Charles R. Merriman
A1 Herbert F. Upchurch
A1 Ralph F. Kampschmidt
YR 1974
UL http://jpet.aspetjournals.org/content/188/3/516.abstract
AB Leukocytic endogenous mediator (LEM) induces numerous changes typical of those seen during the acute phase of inflammation. The possibility that LEM was acting through prostaglandin E1 (PGE1) was investigated. PGE1 failed to mimic the effects of LEM when injected intracisternally or intravenously. Injection of PGE1 intracisternally increased temperature in rats whereas injections of LEM produced hypothermia. Aspirin, an inhibitor of prostaglandin synthesis, did not block LEM induced release of neutrophils from the bone marrow or the lowering of plasma iron levels. The combination of these two findings plus the variety of routes used to administer both PGE1 and aspirin make it unlikely that PGE1 is involved in either lowering of plasma iron or the release of neutrophils from the bone marrow during the acute phase of inflammation. © 1974 by The Williams &amp; Wilkins Co.