RT Journal Article
SR Electronic
T1 THE ABILITY OF PROPRANOLOL TO ANTAGONIZE INDUCED CHANGES IN HEART RATE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 198
OP 206
VO 188
IS 1
A1 J. R. Ledsome
A1 Rosalind P. Kellett
A1 Sally M. Burkhart
YR 1974
UL http://jpet.aspetjournals.org/content/188/1/198.abstract
AB It has been suggested that adrenergic responses to nerve stimulation may be more or less readily antagonized than are responses to exogenous catecholamines. These experiments examine the effects of various doses of propranolol on the increase in heart rate caused by exogenous catecholamine (isoproterenol or norepinephrine) and by endogenous catecholamine (stimulation of the right ansa subclavia) in the same anesthetized dogs. The results show that the degree of antagonism by propranolol of an isoproterenol-induced increase in heart rate is similar to the degree of antagonism of a similar increase in heart rate induced by stimulation of the right ansa subclavia. © 1974 by The Williams & Wilkins Company