RT Journal Article
SR Electronic
T1 APPLICATION OF PRINCIPLES OF STEADY-STATE KINETICS TO MEASURE ACETYLCHOLINE TURNOVER RATE IN RAT SALIVARY GLANDS: EFFECT OF DEAFFERENTATION AND DUCT LIGATION
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 68
OP 77
VO 187
IS 1
A1 Hanin, I.
A1 Cheney, D. L.
A1 Trabucchi,, M.
A1 Massarelli, R.
A1 Wang, C. T.
A1 Costa, E.
YR 1973
UL http://jpet.aspetjournals.org/content/187/1/68.abstract
AB A radio-gas chromatographic method to measure choline and acetylchoine specific activities in tissue extracts has been used to study the effect of parasympathetic decentralization (chorda tympani section) and duct ligation on turnover rates of acetylcholine in the submaxillary and sublingual glands of rats, in vivo. Steady-state kinetic principles were used in the mathematical analysis of the precursor product relationship assuming a simplified kinetic model. This analysis indicates that decentralization significantly reduces acetylcholine turnover rate in the salivary glands, whereas duct ligation has no significant effect on this turnover rate. © 1973 by The Williams & Wilkins Company