RT Journal Article SR Electronic T1 INTERACTION OF INDAZOLE ANALOGS OF LUCANTHONE AND HYCANTHONE WITH CLOSED CIRCULAR DUPLEX DEOXYRIBONUCLEIC ACID JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 385 OP 389 VO 186 IS 3 A1 M. J. WARING YR 1973 UL http://jpet.aspetjournals.org/content/186/3/385.abstract AB The effects of four newly synthesized analogs of the schistosomicidal drugs lucanthone (Miracil D) and hycanthone on the sedimentation properties of bacteriophage PM2 DNA have been investigated. All four were found to remove and reverse the supercoiling of the closed circular duplex deoxyribonucleic acid (DNA) molecules in vitro, in a fashion qualitatively and quantitatively consistent with the supposition that they bind to DNA by intercalation. For three of the drugs the helix unwinding angle associated with their binding to DNA was estimated to be not less than 6.7° for the fourth a lower limit of ≥ 4.3° was calculated. © 1973 by The Williams & Wilkins Co.