PT  - JOURNAL ARTICLE
AU  - ROBERT M. JULIEN
AU  - EVA M. KAVAN
TI  - ELECTROGRAPHIC STUDIES OF A NEW VOLATILE ANESTHETIC AGENT: ENFLURANE (ĒTHRANE)
DP  - 1972 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 393--403
VI  - 183
IP  - 2
4099  - http://jpet.aspetjournals.org/content/183/2/393.short
4100  - http://jpet.aspetjournals.org/content/183/2/393.full
SO  - J Pharmacol Exp Ther1972 Nov 01; 183
AB  - In cats with electrodes chronically implanted in selected nuclei of limbic, sensory and diffuse projection systems, anesthetic concentrations of enflurane (Ēthrane) induced bursts of high voltage spike activity separated by prolonged periods of interictal silence. In addition, residual behavioral and electrographie abnormalities were observed on the second postanesthetic day and they persisted for 14 to 16 days. In subsequent studies, anesthetic concentrations of enflurane augmented evoked responses to peripheral stimulation up to 500% over control levels. The relation of these electrographic effects to the anesthetic state and the possible use of enflurane as a tool in the delineation of mechanisms regulating cortical hyperexcitability are discussed. © 1972 by The Williams & Wilkins Co.