RT Journal Article
SR Electronic
T1 STOICHIOMETRY OF THE DRUG-NICOTINIC RECEPTOR INTERACTION
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 649
OP 652
VO 185
IS 3
A1 R. B. PARKER
A1 C. GOLDFINE
YR 1973
UL http://jpet.aspetjournals.org/content/185/3/649.abstract
AB Appropriate estimation of drug-receptor dissociation constants with pharmacological techniques depends upon the stoichiometry of the reaction involved. The data presented in this paper suggest that both stimulant drugs and competitive antagonists interact on a one-to-one basis with the nicotinic receptor of the guinea-pig lumbrical muscle. © 1973 by The Williams & Wilkins Co.