%0 Journal Article %A BERNARD CENTURY %T A ROLE OF THE DIETARY LIPID IN THE ABILITY OF PHENOBARBITAL TO STIMULATE DRUG DETOXIFICATION %D 1973 %J Journal of Pharmacology and Experimental Therapeutics %P 185-194 %V 185 %N 2 %X The ability of phenobarbital to stimulate drug metabolism by liver was evaluated in rats fed semisynthetic diets containing lipids which varied in their fatty acid compositions. Highest stimulation of drug metabolism was observed in phenobarbital-pretreated animals fed linseed or menhaden oils, which furnish high levels of ω3 type nonessential polyunsaturated fatty acids. The least induction was found in animals fed either beef fat or low levels of corn oil, which furnished very little polyunsaturated fatty acids. The ability of phenobarbital to increase rates of recovery (reciprocal of sleeping time) from hexobarbital was highest in rats fed linseed and menhaden oils. Recovery rates were also highest in phenobarbital-pretreated mice fed menhaden oil. Diet-related differences in recovery from hexobarbital treatment were seen in both phenobarbital- and saline-pretreated mice but not in saline-pretreated rats. These studies call attention to the dietary lipid as a pharmacological tool for varying cellular functions and drug responses, as well as a means of varying fatty acid compositions in tissue components. © 1973 by The Williams & Wilkins Co. %U https://jpet.aspetjournals.org/content/jpet/185/2/185.full.pdf