RT Journal Article
SR Electronic
T1 BRAIN SITES OF PRECIPITATED ABSTINENCE IN MORPHINE-DEPENDENT RATS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 108
OP 115
VO 185
IS 1
A1 WEI, EDDIE
A1 LOH, HORACE H.
A1 WAY, E. LEONG
YR 1973
UL http://jpet.aspetjournals.org/content/185/1/108.abstract
AB The brains of morphine-dependent rats were explored for areas sensitive to naloxone-precipitated withdrawal. Stainless-steel guide cannulas were implanted into different brain areas of male albino rats. One to five days after cannula implantation, physical dependence on morphine was induced by s.c. implantation of a pellet containing 75 mg of morphine base. Naloxone hydrochloride crystals were intracerebrally applied 70 to 76 hours after morphine pellet implantation. After application of naloxone, the abstinence signs of wet shakes and escape behavior were most frequently elicited in the medial thalamus and in medial areas of the diencephalic-mesencephalic junctures. Neocortical, hippocampal, hypothalamic, tegmental, lateral thalamic and striatal areas of the brain were less sensitive to naloxone-precipitated withdrawal. The neuroanatomical pathways related to opioid dependence are discussed. © 1973 by The Williams & Wilkins Company