PT  - JOURNAL ARTICLE
AU  - THOMAS WALLE
AU  - THOMAS E. GAFFNEY
TI  - PROPRANOLOL METABOLISM IN MAN AND DOG: MASS SPECTROMETRIC IDENTIFICATION OF SIX NEW METABOLITES
DP  - 1972 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 83--92
VI  - 182
IP  - 1
4099  - http://jpet.aspetjournals.org/content/182/1/83.short
4100  - http://jpet.aspetjournals.org/content/182/1/83.full
SO  - J Pharmacol Exp Ther1972 Jul 01; 182
AB  - The metabolism of oral propranolol has been studied in patients and dogs by gas chromatography-mass spectrometry. N-desisopropylpropranolol, 1-(α-naphthoxy)-2,3-propyleneglycol, ring hydroxylated 1-(α-naphthoxy)-2, 3-propyleneglycol, α-naphthoxyacetic acid, α-naphthol and 1,4-dihydroxynaphthalene were identified in urine as were unchanged propranolol and the earlier reported metabolites 4-hydroxypropranolol and naphthoxylactic acid. There were no qualitative differences between the patients and dogs. Several of these metabolites have pharmacological activity which may contribute to the diverse effects of propranolol in man. © 1972, by The Williams & Wilkins Company