RT Journal Article
SR Electronic
T1 STUDIES ON THE TRANSPORT OF MORPHINE OUT OF THE PERFUSED CEREBRAL VENTRICLES OF RABBITS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 46
OP 52
VO 181
IS 1
A1 WANG, J. H.
A1 TAKEMORI, A. E.
YR 1972
UL http://jpet.aspetjournals.org/content/181/1/46.abstract
AB Artificial cerebrospinal fluid was perfused between the lateral ventricle and the cisterna magna of anesthetized rabbits. This perfusion system was used to study the transport of morphine out of the ventricles. The passage of morphine from the perfused ventricles to the blood appeared to be a simple diffusion process since the percentage of morphine removed from the perfusion fluid remained constant over a wide range of inflow concentrations in the ventriculocisternal perfusion system. This transport was not inhibited by time concurrent perfusion with structurally related compounds such as codeine, ethylmorphine and naloxone, with organic basic compounds such as cocaine, N-methylnicotinamide and quinine, with an organic acidic compound, p-aminohippurate or with inhibitors such as dinitrophenol and ouabain. © 1972, by The Williams & Wilkins Company