PT  - JOURNAL ARTICLE
AU  - WESLEY G. CLARK
AU  - SANDRA G. MOYER
TI  - THE EFFECTS OF ACETAMINOPHEN AND SODIUM SALICYLATE ON THE RELEASE AND ACTIVITY OF LEUKOCYTIC PYROGEN IN THE CAT
DP  - 1972 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 183--191
VI  - 181
IP  - 1
4099  - http://jpet.aspetjournals.org/content/181/1/183.short
4100  - http://jpet.aspetjournals.org/content/181/1/183.full
SO  - J Pharmacol Exp Ther1972 Apr 01; 181
AB  - Intravenous injections of acetaminophen (5 or 10 mg/kg) or sodium salicylate (20 or 40 mg/kg) 30 minutes prior to administration of leukocytic pyrogen, derived from acute peritoneal exudate cells. effectively inhibited the development of fever in response to a wide range of doses of leukocytic pyrogen. Acetaminophen, 2 mg/kg, and sodium salicylate, 10 mg/kg, did not significantly reduce the response to pyrogen injections. In vitro incubations of leukocytes in the presence of acetaminophen (0.1-3.0 mM) or sodium salicylate (0.1-10.0 mM) inhibited neither activation of blood leukocytes by endotoxin nor the release of leukocytic pyrogen from activated blood or peritoneal leukocytes. Inhibition of the pyrogenic effect of leukocytic pyrogen, rather than impairment of the ultimate release of leukocytic pyrogen, accounts for the antipyretic effects of acetaminophen dium salicylate in the cat. © 1972, by The Williams & Wilkins Company