PT  - JOURNAL ARTICLE
AU  - P. J. BENTLEY
TI  - INHIBITION BY DOPAMINE OF THE HYDROOSMOTIC RESPONSE (WATER TRANSFER) OF THE TOAD BLADDER TO VASOPRESSIN
DP  - 1972 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 155--160
VI  - 181
IP  - 1
4099  - http://jpet.aspetjournals.org/content/181/1/155.short
4100  - http://jpet.aspetjournals.org/content/181/1/155.full
SO  - J Pharmacol Exp Ther1972 Apr 01; 181
AB  - Dopamine (10-7 M) competitively decreased the hydro-osmotic response of the toad urinary bladder to vasopressin. Norepinephrine and epinephrine also decreased the effect of vasopressin but isoproterenol (10-4 M) was much less active. None of the catecholamines influenced the osmotic permeability of the bladder in time absence of vasopressin. The hydro-osmotie action of cyclic adenosine monophosphate was unaffected by dopamine (10-4 M) but that of theophylline (20 mM) was abolished. Either alpha or beta adrenergic blockers (phentolamine or propanolol) abolished time antagonism of dopamine to vasopressin. In contrast only phentolamine could reduce this action of norepinephrine. It is suggested that dopamine competitively antagonizes the effect of vasopressin possibly on adenyl cyclase. © 1972, by The Williams & Wilkins Company