PT  - JOURNAL ARTICLE
AU  - CONKLIN, K. A.
AU  - CHOU, S. C.
TI  - THE EFFECTS OF ANTIMALARIAL DRUGS ON UPTAKE AND INCORPORATION OF MACROMOLECULAR PRECURSORS BY <em>TETRAHYMENA PYRIFORMIS</em>
DP  - 1972 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 158--166
VI  - 180
IP  - 1
4099  - http://jpet.aspetjournals.org/content/180/1/158.short
4100  - http://jpet.aspetjournals.org/content/180/1/158.full
SO  - J Pharmacol Exp Ther1972 Jan 01; 180
AB  - The effects of quinine. chloroquine, primaquine and quinacrine on the uptake and incorporatioin of 14C-thymidine, 14C-uridine and 14C-amino acids were studied in synchronized Tetrahymena pyriformis. Quinacrine inhibited the incorporation of thymidine and uridimme but had little effect on the uptake of these precursors, which indicates that this antimalarial drug directly inhibits the synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) .The inihibitory effect of quinacrine on amino acid incorporation. however. appears to be due to an inhibition of uptake of these precursors. Quinine, chloroquine and primaquine inhibited the uptake of all precursors studied and this appears to be one of the mechanisms of the drugs for blocking precursor incorporation into DNA. RNA and protein. © 1972, by The Williams & Wilkins Company