PT  - JOURNAL ARTICLE
AU  - GREENBERG, S.
AU  - LONG, J. P.
AU  - DIECKE, F. P. J.
TI  - THE EFFECT OF 4 ,4'-BIPHENYLENEBIS-[(2-OXOETHYLENE)-BIS-(2,2-DIETHOXYETHYL)]DIMETHYLAMMONIUM DIBROMIDE (DMAE) ON THE RESPONSES OF TISSUES INNERVATED BY SHORT ADRENERGIC NEURONS TO CATECHOLAMINES AND IONIC STIMULANTS
DP  - 1971 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 161--170
VI  - 179
IP  - 2
4099  - http://jpet.aspetjournals.org/content/179/2/161.short
4100  - http://jpet.aspetjournals.org/content/179/2/161.full
SO  - J Pharmacol Exp Ther1971 Nov 01; 179
AB  - The effect of DMAE on contractile responses of tissues innervated by short adrenergic neurons to norepinephrine, tyramine, KC1, BaCl3, CaCI2 and transmural stimulation was evaluated with the superfused rat vas deferens and guinea-pig seminal vesicle preparations. DMAE enhanced the responses of these tissues to tyramine, BaCl3, and transmural stimulation in concentrations (1-10 µg/ml) which did not affect the responses to norepinephrine, KCl or CaCl3,. When CaCl3 was omitted from the superfusate, DMAE enhanced the responses of the vas deferens to CaCl3 and BaCl3. Nerve terminal blockade with bretylium or guanethidine and depletion of neurotranemitter with reserpine abolished DMAE-induced potentiation of the responses of these tissues to BaCl and CaCl3. These results demonstrate that the effects of DMAE appear to be localized at the postganglionic nerve terminal membrane. The results also suggest that DMAE may alter neuronal permeability to divalent cations involved with the release of neurotransmitter. © 1971 by The Williams & Wilkins Co.