RT Journal Article SR Electronic T1 ADRENERGIC RESPONSES IN THE HUMAN EYE JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 47 OP 55 VO 179 IS 1 A1 MAURICE E. LANGHAM A1 YOSHIAKI KITAZAWA A1 ROBERT W. HART YR 1971 UL http://jpet.aspetjournals.org/content/179/1/47.abstract AB The responses of the pupil, intraocular pressure and aqueous humor dynamics have been studied. Norepinephrine induced pupil dilatation, decreased intraocular pressure and increased tonographic outflow facility. The responses were dose-dependent. Isoproterenol was without effect on either the pupil or the outflow facility but decreased intraocular pressure. Epinephrine, at low concentrations, decreased intraocular pressure without an increase in outflow facility and without pupil dilatation. At higher concentrations an increase in outflow facility and mydriasis took place. Protriptyline induced potentiation of the ocular response to both endogenously released and exogenously administered norepinephrine: however, it induced little potentiation to epinephrine and none to isoproterenol. © 1971 by The Williams & Wilkins Company