RT Journal Article
SR Electronic
T1 ANTISCHISTOSOMAL ACTIVITY OF A NITROVINYLFURAN DERIVATIVE (SQ 18,506) IN RHESUS MONKEYS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 411
OP 416
VO 178
IS 2
A1 D. G. ERICKSON
A1 J. G. BOURGEOIS
A1 E. H. SADUN
A1 E. BUEDING
YR 1971
UL http://jpet.aspetjournals.org/content/178/2/411.abstract
AB Administration of trans-5-amino-3[2-(5-nitro-2-furyl)-vinyl]-1,2,4-oxadiazole (SQ 18,506) to rhesus monkeys infected with either Schistosoma mansoni or Schistosoma japonicum resulted in marked chemotherapeutic activity and no apparent host toxicity. The number of worms recovered from the treated monkeys was reduced considerably. The surviving worms were stunted. Damage to these worms was revealed also by a very marked decrease in the number of eggs present in the tissues of the host and in the feces, by frequent abnormalities in the female reproductive system and by decreased glycogen levels in the males. © 1971 by The Williams & Wilkins Co.