@article {ERICKSON411, author = {D. G. ERICKSON and J. G. BOURGEOIS and E. H. SADUN and E. BUEDING}, title = {ANTISCHISTOSOMAL ACTIVITY OF A NITROVINYLFURAN DERIVATIVE (SQ 18,506) IN RHESUS MONKEYS}, volume = {178}, number = {2}, pages = {411--416}, year = {1971}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Administration of trans-5-amino-3[2-(5-nitro-2-furyl)-vinyl]-1,2,4-oxadiazole (SQ 18,506) to rhesus monkeys infected with either Schistosoma mansoni or Schistosoma japonicum resulted in marked chemotherapeutic activity and no apparent host toxicity. The number of worms recovered from the treated monkeys was reduced considerably. The surviving worms were stunted. Damage to these worms was revealed also by a very marked decrease in the number of eggs present in the tissues of the host and in the feces, by frequent abnormalities in the female reproductive system and by decreased glycogen levels in the males. {\textcopyright} 1971 by The Williams \& Wilkins Co.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/178/2/411}, eprint = {https://jpet.aspetjournals.org/content/178/2/411.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }